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The effects of pulmonary rehabilitation program on oxidative stress biomarker and antioxidant enzymes activities in chronic obstructive pulmonary disease patients and in healthy subjects

Imen Ben Cheikh Rejbi, Imed Laatiri, Afef Chouchane, Abdelkarim Zbidi, Abdelhamid Kerkeni, Zouhair Tabka.

Abstract
Objective: The aim of this study was to evaluate the effects of pulmonary rehabilitation on oxidative stress biomarker (Thiobarbituric acid substances TBARS) and antioxidant enzymes activities (superoxide dismutase SOD, glutathione peroxidise GPx and catalase CAT) in patients with chronic obstructive pulmonary disease (COPD) compared to healthy subjects.
Material and Methods: The study included 26 patients with COPD and 12 healthy subjects. The patients were divided into 2 groups (16 trained and 10 untrained). Trained groups performed 45 min individualized exercise training enrolled to an 8 weeks pulmonary rehabilitation program 3 times a week. Prior to and after the programme, exercise testing and pulmonary function were evaluated. Antioxidant enzymes activities were measured by spectrophotometry and spectrofluorimetry was used for plasma levels of thiobarbituric acid substances.
Results: After the program, exercise capacity improved significantly in trained groups. At baseline, plasma TBARS were significantly increased in patients with COPD compared to the healthy subjects (p

Key words: Chronic obstructive pulmonary disease; healthy subjects; pulmonary rehabilitation; oxidative stress biomarker; antioxidant enzymes


 
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How to Cite this Article
Pubmed Style

Rejbi IBC, Laatiri I, Chouchane A, Zbidi A, Kerkeni A, Tabka Z. The effects of pulmonary rehabilitation program on oxidative stress biomarker and antioxidant enzymes activities in chronic obstructive pulmonary disease patients and in healthy subjects. International Journal of Therapies and Rehabilitation Research. 2012; 1(2): 1-10. doi:10.5455/ijtrr.00000011



Web Style

Rejbi IBC, Laatiri I, Chouchane A, Zbidi A, Kerkeni A, Tabka Z. The effects of pulmonary rehabilitation program on oxidative stress biomarker and antioxidant enzymes activities in chronic obstructive pulmonary disease patients and in healthy subjects. www.scopemed.org/?mno=21587 [Access: August 21, 2017]. doi:10.5455/ijtrr.00000011



AMA (American Medical Association) Style

Rejbi IBC, Laatiri I, Chouchane A, Zbidi A, Kerkeni A, Tabka Z. The effects of pulmonary rehabilitation program on oxidative stress biomarker and antioxidant enzymes activities in chronic obstructive pulmonary disease patients and in healthy subjects. International Journal of Therapies and Rehabilitation Research. 2012; 1(2): 1-10. doi:10.5455/ijtrr.00000011



Vancouver/ICMJE Style

Rejbi IBC, Laatiri I, Chouchane A, Zbidi A, Kerkeni A, Tabka Z. The effects of pulmonary rehabilitation program on oxidative stress biomarker and antioxidant enzymes activities in chronic obstructive pulmonary disease patients and in healthy subjects. International Journal of Therapies and Rehabilitation Research. (2012), [cited August 21, 2017]; 1(2): 1-10. doi:10.5455/ijtrr.00000011



Harvard Style

Rejbi, I. B. C., Laatiri, I., Chouchane, A., Zbidi, A., Kerkeni, A. & Tabka, Z. (2012) The effects of pulmonary rehabilitation program on oxidative stress biomarker and antioxidant enzymes activities in chronic obstructive pulmonary disease patients and in healthy subjects. International Journal of Therapies and Rehabilitation Research, 1 (2), 1-10. doi:10.5455/ijtrr.00000011



Turabian Style

Rejbi, Imen Ben Cheikh, Imed Laatiri, Afef Chouchane, Abdelkarim Zbidi, Abdelhamid Kerkeni, and Zouhair Tabka. 2012. The effects of pulmonary rehabilitation program on oxidative stress biomarker and antioxidant enzymes activities in chronic obstructive pulmonary disease patients and in healthy subjects. International Journal of Therapies and Rehabilitation Research, 1 (2), 1-10. doi:10.5455/ijtrr.00000011



Chicago Style

Rejbi, Imen Ben Cheikh, Imed Laatiri, Afef Chouchane, Abdelkarim Zbidi, Abdelhamid Kerkeni, and Zouhair Tabka. "The effects of pulmonary rehabilitation program on oxidative stress biomarker and antioxidant enzymes activities in chronic obstructive pulmonary disease patients and in healthy subjects." International Journal of Therapies and Rehabilitation Research 1 (2012), 1-10. doi:10.5455/ijtrr.00000011



MLA (The Modern Language Association) Style

Rejbi, Imen Ben Cheikh, Imed Laatiri, Afef Chouchane, Abdelkarim Zbidi, Abdelhamid Kerkeni, and Zouhair Tabka. "The effects of pulmonary rehabilitation program on oxidative stress biomarker and antioxidant enzymes activities in chronic obstructive pulmonary disease patients and in healthy subjects." International Journal of Therapies and Rehabilitation Research 1.2 (2012), 1-10. Print. doi:10.5455/ijtrr.00000011



APA (American Psychological Association) Style

Rejbi, I. B. C., Laatiri, I., Chouchane, A., Zbidi, A., Kerkeni, A. & Tabka, Z. (2012) The effects of pulmonary rehabilitation program on oxidative stress biomarker and antioxidant enzymes activities in chronic obstructive pulmonary disease patients and in healthy subjects. International Journal of Therapies and Rehabilitation Research, 1 (2), 1-10. doi:10.5455/ijtrr.00000011








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